The utility of a cell-based disease model relies upon generation of a demonstrable phenotype that closely reflects the underlying biology of the disease. We develop human iPSC-derived cardiac and neuronal disease models of your choice depending on your requirements to enable target or phenotypic drug discovery, as well as guiding structure–activity relationship (SAR) studies.
(A) Control or ET-1 treated cardiomyocytes were stained for BNP (green) and nuclei (blue). (B) Quantification of high content images showing total nuclear area (left) or BNP expression (right) in the presence or absence of ET-1. (C) ET-1 induced NT-proBNP secretion, measured by AlphaLISA, was rescued by treatment with Verapamil.