How Does STAR-CRISPR Measure Up?
CRISPR-based systems have two key components:
- Guide RNA (gRNA) — a short RNA sequence matching the target DNA sequence to be edited
- DNA cutting enzyme — typically Cas9 or their derivatives
Among all the CRISPR-based systems available to edit iPSCs, STAR-CRISPR stands out with:
Unparalleled efficiencies in gene knock-in and knock-out
Minimal off-target editing
STAR-CRISPR offers about a 90% of Knock-out efficiency, surpassing Cas9 and MAD7
Knock-in efficiency is 2–3 times higher than other leading CRISPR-based methods when applied to iPSCs
STAR-CRISPR significantly mitigates the risk of unintended edits, also called off-targets, when compared to Cas9 in iPSCs
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As more and more drug innovators look to capitalize on the unique value only iPSCs can deliver, they look to Ncardia as their qualified collaborator to join them.
Karin, Scientist
iPSC technology expert
