Disease-relevant screening assays
tailored to your needs
Bringing together human iPSC technology, disease knowledge and automation
Ncardia’s expertise and in-house screening capabilities facilitate the efficient generation and application of relevant in vitro models at any stage of your discovery pipeline. Our assays are designed to best mimic your disease of interest and increase confidence in Go/No Go decisions.
Benefits of Ncardia's Custom Screening Services
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Specific to your Research Question
Study the phenotype and readout
of your interest
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Developed by Proven Experts
Enhance robustness and reproducibility
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Translational Results
Testing on relevant
human biology
Patient-derived, genome-edited and environmentally induced disease models
Work with your own iPSC lines, our proprietary lines, or leverage our sourcing and reprogramming services.
If required, you can benefit from highly efficient genome editing for your iPSC line of choice with our proprietary STAR CRISPR technology.
To maximize reproducibility, cells are differentiated at the scale and volume you need with a rigorously characterized for identity and functionality.
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Innovate, de-risk and enhance translational success
Our expertise in iPSC technology and profound understanding of its applications enable our team to develop everything from pilot and validation studies to full screening campaigns.
We offer a multitude of cell models, technologies and readouts that can be combined and applied to any therapeutic modality.
- Monoculture, co-culture and triculture models
- 2D or 3D formats
- Low to high throughput
- Multiplexing
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Achieve a high-throughput format with robust and reproducible results
Integrating iPSC-based assays in large screening campaigns doesn't have to be a challenge anymore.
Our team has the capabilities and expertise to miniaturize - reducing costs - and automate relevant cell-based assays while keeping a strong focus on delivering high-quality and reproducible data.
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Discover our broad range of technology platforms and assay endpoints
Examples of Custom Projects
Confirming compound binding and MoA in atrial cardiomyocytes
- Large-scale differentiation of pure iPSC-derived atrial cardiomyocytes
- Assay development and suitability testing for target drugs
- Customized MEA assay to assess RNAi-mediated knockdown and compound screening
Screening safety and efficacy of antisense oligonucleotides (ASOs)
- Large-scale differentiation and characterization of highly pure hiPSC-derived neurons
- Generation of a single batch large enough for the study, reducing variability
- Automation and miniaturization of assays to achieve low-intra plate variation
Assessing therapeutic's efficacy in Friedreich's Ataxia (FA)
- Differentiation of healthy and disease iPSC lines into cardiomyocytes
- Disease model validation and development of functional assays to study FA phenotype
- Project provided validation of target and efficacy of therapeutic candidate
Your Trusted Partner to Maximize Long-term Success
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Define your Needs
We sit together to understand your specifications and co-develop a plan
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Plan the Process
We set a project plan with clear timelines and milestones
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Execute and Report
Follow progress with frequent and transparent communication
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Plan for the Future
We explain the data and discuss how to support you in your next steps
What our Clients Think of Us
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Senior Scientist
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Scientist
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Project Manager
Incorporate relevant cell models
in your drug discovery pipeline
We’re ready to help make your next step the very best it can be. So let’s start with a conversation – about your vision, goals and expectations for your drug discovery projects.
![Kim 2](https://www.ncardia.com/hubfs/Kim%202.png?noresize)