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Cardiovascular Safety & Toxicity Evaluation Services

Assessment of drug safety and toxicity is complex and can be time consuming. Cardiac toxicity may be observed after short or long-term compound exposure. Additionally, structural and functional aspects of cardiac toxicity need to be considered. Uncovering potential cardiotoxic effects of drug candidates earlier in the drug discovery process will decrease drug attrition rates and saves needed resources. Ncardia provides integrated cardiovascular services to enhance the assessment of cardiac safety and toxicity of drug candidates. All services utilize functional human iPSC-derived cell models in qualified assays.

Safety Services

MEA

Acute Cardiac Safety - MEA Analysis

Delivers an acute cardiac safety profile of your compounds following the current protocols of the CiPA initiative for microelectrode arrays (MEA) analysis.

EBT

Endothelial Barrier Toxicity

Assessment of drug-induced vascular leakage using high-content, real-time and label-free impedance-based technology that monitors changes in electrical impedance across the endothelial cell monolayer.

CT

Calcium Transients

High-throughput screening of compound effects on cardiomyocyte electrophysiology by analyzing the intracellular calcium transients.

I

Acute & Chronic Cytotoxicity - Impedance Analysis

Provides an acute and long-term cardiac safety profile based on label-free impedance analysis of your compounds using hiPSC-derived cardiomyocytes.

CT

Structural Cardiotoxicity - Troponin Detection

Delivers a structural cardiotoxicity profile of your compounds based on the detection of cardiac specific biomarkers like Troponin I release by hiPSC-derived cardiomyocytes.

 

MP

Multiparametric Functional & Structural Cardiotoxicity

An analysis by impedance (contractility), electrophysiology and biomarker release (structural).

CPS

Customized Project Service

Get in contact with us to discuss a custom assay development project. Ncardia has a menu of qualified human iPSC-derived cell models, technology platforms and domain experts to develop and execute an assay that is build to your specifications.