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Key publications


  • Spotlight Publication: Kopljar I, Lu H.R, Van Ammel K, Tekle F, Teisman A, Gallacher D.J. Development of a Human iPSC Cardiomyocyte-Based Scoring System for Cardiac Hazard Identification in Early Drug Safety De-risking. Stem Cell Reports.

  • Sottas V, Wahl CM, Trache MC, Bartolf-Kopp M, Cambridge S, Hecker M, Ullrich ND. Improving electrical properties of iPSC-cardiomyocytes by enhancing Cx43 expression. J Mol Cell Cardiol

  • He H, Bertin MJ, Wu S, Wahome PG, Beauchesne KR, Youngs RO, Zimba PV, Moeller PDR, Sauri J, Carter GT. Cyanobufalins: Cardioactive Toxins from Cyanobacterial Blooms. J Nat Prod

  • Cerea A, Caprettini V, Bruno G, et al. Selective intracellular delivery and intracellular recordings combined on MEA biosensors. arXiv

  • August Newsletter Feature: MacQueen LA, Sheehy SP, Chantre CO, Zimmerman JF, Pasqualini, FS, Parker KK, et al. A tissue-engineered scale model of the heart ventricle. Nat Biomed Eng

  • Sottas V, Wahl C-W, et al. Improving electrical properties of iPSC-cardiomyocytes by enhancing Cx43 expression. J Mol Cell Card

  • Pugsley MK, Harter LH, de Korte T, Connaughton C, Authier S, Curtis J. Safety pharmacology methods and regulatory considerations evolve together. J Pharm Tox Meth

  • Bot CT, Juhasz K, Haeusermann F, Polonchuk L, Traebert M, Stoelzle-Feix S. Cross-site comparison of excitation-contraction coupling using impedance and field potential recordings in hiPSC cardiomyocytes. J Pharm Tox Meth

  • Silbernagel N, Walecki M, et al. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB Journal

  • Hu, N., Wang, T., Wan, H., Zhuang, L., KETTENHOFEN, R., Zhang,X., Zhang, Y.S., Xu, W., Gossmann, M., BOHLEN, H., Hou, X., Wang, P.. Synchronized electromechanical integration recording of cardiomyocytes. Biosensors and Bioelectronics

  • Goineau S, Castagné V. Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers. J Pharm Tox Meth

  • Baburina I, Varkevisser R, Schramm A, et al. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. Pharm. Res.

  • De Lorenzo C, Paciello R, Riccio G, et al. Cardiotoxic effects of the novel approved anti-ErbB2 agents and reverse cardioprotective effects of ranolazine. OncoTargets and Therapy

  • Kao I, Xiong Y, Steffen A, et al. Preclinical In Vitro Safety Investigations of Submicron Sized Hemoglobin Based Oxygen Carrier HbMP-700. Art Org

  • Cunha-Oliveira T, Ferreira LL, Coelhoa AR, Deusa CM, Oliveira PJ. Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes. Tox App Pharm

  • Yamazaki D, Kitaguchi T, Ishimura M, et al. Proarrhythmia risk prediction using human induced pluripotent stem cell-derived cardiomyocytes. J Pharm Sci

  • Tertoolen LGJ, Braam SR, van Meer BJ, Passier R, Mummery CL. Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes. Biochemical and Biophysical Research Communications

  • Edington CD, Chen WLK, Geishecker E, et al. Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies. Scientific Reports

  • Ncardia Conference Report. Mulder P, de Korte T, Dragicevic E, Kraushaar U, Printemps R, Vlaming MLH, Braam SR, and Valentin JP. Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report. J Pharmacol Toxicol Methods

  • Kopljar I, Hermans AN, Teisman A, Gallacher DJ, and Lu HR. Impact of calcium-sensitive dyes on the beating properties and pharmacological responses of human iPS-derived cardiomyocytes using the calcium transient assay. J Pharmacol Toxicol Methods

  • Nawroth C, Scudder LL, Halvorson RT, Tresback J, Ferrier JP, Sheehy SP, Cho A, Kannan S, Sunyovszki I, and Goss JA. Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications. Biofabrication

  • Goversen B, Becker N, Stoelzle-Feix S, Obergrussberger A, Vos MA, van Veen T, Fertig N, and de Boer TP. A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time. Frontiers in Physiology


  • Passini E, Britton OJ, Lu HR, Rohrbacher J, Hermans AN, Gallacher DJ, Greig RJH, Bueno-Orovio A, Rodriguez B. Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity. Front Physiol.

  • Gao X, Yin Y, Daily NJ, et al. Computational Model for Simulating Drug-Induced Arrhythmia Sensitivity of Human iPSC-derived Cardiomyocytes. bioRxiv

  • Maoz BM, Herland A, et al. Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities. Lab on a Chip

  • Lind JU, Busbee TA, Valentine AD, et al. Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing. Nature Materials

  • Ligneau X, Shah RR, Berrebi-Bertrand I, et al. Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies. Br J Pharmacol.

  • Lei CL, Wang K, Clerx M, Johnstone RH, Hortigon-Vinagre MP, Zamora V, Allan A, Smith GL, Gavaghan DJ, Mirams GR and Polonchuk L. Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology. Frontiers in Physiology

  • Kopljar I, De Bondt A, Vinken P, Teisman A, Damiano B, Goeminne N, Van den Wyngaert I, Gallacher D, Lu, HR. Combining Video Microscopy Motion Analysis and Detection of Cardiac Injury Biomarkers to Evaluate Chronic Cardiotoxicity in hiPS Cardiomyocytes. J Pharm Tox Meth

  • Bodi I, Grünert SC, Becker N, Stoelzle-Feix S, Spiekerkoetter U, Zehender M, Bugger H, Bode C, Odening KE. Mechanisms of acquired long QT syndrome in patients with propionic academia. Heart Rhythm

  • Kujala VJ, Pasqualini FS, Goss JA, Nawrotha JC, Parker KK. Laminar ventricular myocardium on a microelectrode array-based chip. Journal of Materials Chemistry B

  • Rehnelt S, Malan D, Juhasz K, Wolters B, Doerr L, Beckler M, Kettenhofen R, Bohlen H, Bruegmann T, Sasse P. Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation. Int J Mol Sci

  • Gélinas R, El Khoury N, Chaix MA, Beauchamp C, Alikashani A, Ethier N, Boucher G, Villeneuve L, Robb L, Latour F, Mondesert B, Rivard L, Goyette P, Talajic M, Fiset C, Rioux JD. Characterization of a Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Model for the Study of Variant Pathogenicity: Validation of a KCNJ2 Mutation. Circ Cardiocasc Genet

  • Lapp H, Bruegmann T, Malan D, Friedrichs S, Kilgus C, Heidsieck A, Sasse P. Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes. Sci Rep

  • Polonchuk L, Chabria M, Badi L, Hoflack J-C, Figtree G, Davies MJ, Gentile C. Cardiac spheroids as promising in vitro models to study the human heart microenvironment. Sci Rep

  • Batista L, Bastogne T, Delaunois A, Valentin V-P, Atienzar F. A novel statistical signal processing method to estimate effects of compounds on contractility of cardiomyocytes using impedance assays. SBS

  • Rana P, Luerman G, Hess D, Rubitski E, Adkins K, Somps C. Utilization of iPSC-derived human neurons for high-throughput drug-induced peripheral neuropathy screening. Toxicol In VItro

  • Pugsley MK, de Korte T, Authier S, Huang H, Accardi MV, Curtis MJ. Safety pharmacology methods and models in an evolving regulatory environment. J Pharm Tox Meth

  • Tertoolen LGJ, Braam SR, van Meer BJ, Passier R, Mummery CL. Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Comm

  • Devarasetty M, Forsythe S, Shupe T D, Soker S, Bishop C E, Atala A and Skardal A. Optical Tracking and Digital Quantification of Beating Behavior in Bioengineered Human Cardiac Organoids. Biosensors (Basel)

  • Koci B, Luerman G, Duenbostell A, Kettenhofen R, Bohlen H, Coyle L, Knight B, Ku W, Volberg W, Woska JR, Brown MP. An impedance-based approach using human iPSC-derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilities. Toxicol Appl Pharmacol

  • Franz D, Olsen H L, Klink O, Gimsa J. Automated and manual patch clamp data of human induced pluripotent stem cell-deriveddopaminergic neurons. Sci Data
  • Zhang N, Milleret V, Thompson-Steckel G, Huang NP, Vörös J, Simona BR, Ehrbar M. Soft Hydrogels Featuring In-Depth Surface Density Gradients for the Simple Establishment of 3D Tissue Models for Screening Applications. SLAS Discov


  • Zhao L., Zhang B. Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosisin cardiomyocytes. Sci Rep

  • Johan U. Lind, Travis A. Busbee, Alexander D. Valentine, et al. Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing. Nat Mater

  • Blinova K, Stohlman J, Vicente J, et al. Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias. Toxicol Sci

  • Hortigon-Vinagre MP, Zamora V, Burton FL, Green J, Gintant GA, Smith GL. The Use of Ratiometric Fluorescence Measurements of the Voltage Sensitive Dye Di-4-ANEPPS to Examine Action Potential Characteristics and Drug Effects on Human Induced Pluripotent StemCell-Derived Cardiomyocytes. Toxicol Sci

  • Hartmann T, Overhagen S, Ouwens DM, Raschke S, Wohlfart P, Tennagels N, Wronkowitz N, Eckel J. Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function. Cardiovasc Diabetol

  • Hertz LD, Owzar K, Lessans S, et al. Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy. Clin Cancer Res

  • Monnerat G, Alarcón ML, Vasconcellos LR, et al. Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice. Nat Commun. 2016 Nov 24. PMID: 27882934

  • Kopljar I, Gallacher DJ, De Bondt A, Cougnaud L, Vlaminckx E, Van den Wyngaert I, Lu HR. Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells Transl Med

  • Goßmann M, Frotscher R, Linder P, Neumann S, Bayer R, Epple M, Staat M, Artmann AT, Artmann GM. Mechano-Pharmacological Characterization of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells. Cell Physiol Biochem

  • Mathieu S, El Khoury N, Rivard K, Gelinas R, Goyette P, Paradis P, Nemer M, Fiset C. Reduction in Na+ current by angiotensin II is mediated by PKCα in mouse and human-induced pluripotent stem cell–derived cardiomyocytes. Heart Rhythm

  • Bodi I, Grünert S, Becker N, Stölzle-Feix S, Spiekerkoetter U, Zehender M, Bugger H, Bode C, Odening KE. Mechanisms of acquired long QT syndrome in patients with propionic academia. Heart Rhythm

  • Aratyn-Schaus Y, Pasqualini FS, Yuan H, McCain ML, Ye GJC, Sheehy SP, Campbell PH, and Parker KK. Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac celltherapy. Cell Biol

  • Frotscher R, Muanghong D, Dursun G, Goßmann M, Temiz-Artmann A, Staat M. Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue. J Biomechanics